PDRN / NAD+ Skin Rejuvenation

At Lakeside Regenerrative Clinic, PDRN and NAD+ based treatments are used as part of personalised skin-rejuvenation and regenerative-care approaches. These treatments focus on supporting skin repair, cellular function, hydration, and overall skin quality. The specific treatment protocol depends on the product used, method of administration, skin condition, and individual patient needs.

1. Principle

The principle of PDRN and NAD+ treatments is to support the skin's natural repair and cellular processes and improve overall skin quality.

PDRN (Polydeoxyribonucleotide) is a DNA-derived biopolymer that has been studied for its role in tissue repair and regeneration. NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme involved in cellular energy production and several cellular processes.

Depending on the treatment protocol, these approaches may support:

• Skin repair and regeneration
• Collagen and extracellular matrix support
• Improvement in skin hydration and texture
• Cellular energy and metabolic processes
• Skin firmness and elasticity
• Overall skin quality and rejuvenation

2. Mechanism

PDRN is thought to support tissue repair through mechanisms involving nucleotide availability and signalling pathways associated with cellular regeneration. It has been studied for its effects on fibroblast activity, tissue repair, and the formation of extracellular matrix components.

NAD+ plays an important role in cellular metabolism and energy transfer. It also participates in cellular processes related to DNA repair and maintaining cellular function. NAD+ levels and metabolism are associated with several biological processes involved in cellular ageing.

The clinical effects of PDRN and NAD+ treatments depend on the formulation, route of administration, treatment protocol, and individual patient response. Evidence and approved uses may also differ between products and indications.

Overall approach:

PDRN / NAD+ → Cellular and tissue support → Repair and regeneration → Improved skin quality

3. Indications

PDRN and NAD+ based treatments may be considered as part of a personalised skin-rejuvenation plan for selected patients.

Potential aesthetic indications include:

• Dull or tired-looking skin
• Uneven skin texture
• Fine lines and early signs of ageing
• Reduced skin firmness and elasticity
• Dehydrated or compromised-looking skin
• Skin-quality concerns following environmental or photo-induced damage
• Overall skin rejuvenation

PDRN may also be considered in selected regenerative dermatology applications, depending on the specific product and clinical indication.

Treatment selection is based on the patient's skin condition, medical history, treatment goals, and the specific formulation being used.

4. Contraindications & Precautions

Suitability depends on the specific PDRN or NAD+ formulation, route of administration, and individual patient factors. A medical assessment should be completed before treatment.

Potential contraindications may include:

• Known hypersensitivity to the treatment or its components
• Active infection or significant inflammation at the treatment site
• Open wounds or severely compromised skin
• Certain uncontrolled medical conditions
• Previous significant adverse reactions to injectable treatments, where applicable

Important precautions include:

• Pregnancy and breastfeeding, depending on the product and treatment protocol
• Bleeding or clotting disorders
• Use of anticoagulant or antiplatelet medications
• Significant allergies or previous reactions to injectable products
• Active inflammatory skin conditions
• Recent dermatological, cosmetic, or surgical procedures

Patients should provide a complete medical history, including current medications, allergies, previous treatments, and relevant medical conditions.

PDRN / NAD+ Treatment at Lakeside Regenerrative Clinic

At Lakeside Regenerrative Clinic, PDRN and NAD+ treatments are considered as part of an individualised approach to skin health and rejuvenation. Our team evaluates the patient's skin condition, medical history, treatment objectives, and suitability before recommending a specific protocol.

Patients are counselled regarding the expected benefits, limitations, treatment schedule, and potential risks before proceeding.

Consult our dermatology team to determine whether PDRN or NAD+ treatment is appropriate for your individual skin concerns.